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Jamie Kramer

PhD (Memorial)


Associate Professor

Department member since 2019

Tupper 10-M
jkramer[at]dal.ca

Research:

Epigenetics and chromatin in brain function


Research Areas

Epigenetics and chromatin in brain function

Mutations in genes encoding proteins that regulate chromatin structure are one of the most frequent causes of neurodevelopmental disorders, like Autism and Intellectual Disability. We still have very limited knowledge about how chromatin can impact brain function. The main goals of the Kramer lab are: 1) To learn more about the role of epigenetics and chromatin in regulation of learning and memory. 2) To understand the disease mechanisms associated with neurodevelopmental disorders that are caused by disrupted chromatin regulation. We are especially focused on epigenetic regulatory complexes involved in histone modification (acetylation/methylation) and ATP-dependent chromatin remodelling (SWI/SNF superfamily). We take a multidisciplinary systems approach, combining Drosophila behaviour, neuron specific transcriptomics and epigenomics, bioinformatics, developmental biology. Check out our publications on Google Scholar.

Keywords:
Drosophila melanogaster, Epigenetics, Chromatin, Learning and Memory, Mushroom Bodies, Neurodevelopmental Disorders, RNA/ChIP/ATAC-seq

Graduate Students

Taryn Jakub MSc
Spencer Jones PhD
Nicholas Raun PhD

Publications

  1. Chubak M.C., Nixon K.C.J., Stone M.H., Raun N., Rice S.L., Sarikahya M., Jones S.G., Lyons T.A., Jakub T.E., Mainland R.L.M., Knip M.J., Edwards T.N., and Kramer, J.M., (2019) Individual components of the SWI/SNF chromatin remodeling complex have distinct roles in memory neurons of the Drosophila mushroom body Dis. Model Mech. 12(3):pii: dmm037325 [PubMed]
  2. Nixon, K.C.J.*, Rousseau, J.*, Stone, M.H., Sarikahya, M., Ehresmann, S., Mizuno, S., Matsumoto, N., Miyake, N., DDD study, Baralle, D., McKee, S., Izumi, K., Ritter, A., Heide, S., Héron, D., Depienne, C., Titheradge, H., Kramer, J.M.*, and Campeau, P.M.*, (2019) A syndromic neurodevelopmental disorder caused by mutations in SMARCD1, a core SWI/SNF subunit needed for context dependent neuronal gene regulation in flies Am J Hum Genet. 104(4):596-610 [PubMed]
  3. Riahi H., Brekelmans C., Foriel S, Merkling S.H., Kleefstra T., van Rij R.P., Kramer J.M.*, Schenck A.*, (2019) The histone methyltransferase G9a regulates tolerance to oxidative stress-induced energy consumption PLoS Biol. 17(3):e2006146 [PubMed]
  4. Jones S.G., Nixon K.C.J., and Kramer J.M., (2018) Mushroom body specific transcriptome analysis reveals dynamic regulation of learning and memory genes after acquisition of long-term courtship memory G3: Venes, Genomes, Genetics 8(11):3433-3446 [PubMed]