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Daniel A. Kane

PhD (East Carolina University)


Adjunct Professor (Dalhousie University)

Assistant Professor (St. Francis Xavier University)
Department member since 2017

Antigonish, NS
dkane@stfx.ca
Lab Homepage

Research:

Exercise metabolism, mitochondria, monocarboxylate metabolism


Research Areas

My research explores the bioenergetic causes and consequences of mitochondrial fitness. Past work studied the underlying bioenergetic links to insulin resistance, with a focus on mitochondrial reactive oxygen species in muscle. Current work emphasizes the intersection of non-mitochondrial (i.e., glycolytic) and mitochondrial (oxidative phosphorylation) metabolism, to help address the broader question: How does exercise affect mitochondrial fitness, and how does mitochondrial fitness affect exercise capacity and metabolic health?

Publications

  1. D'Souza K, Kane DA, Touaibia M, Kershaw EE, Pulinilkunnil T, Kienesberger PC., (2017) Autotaxin Is Regulated by Glucose and Insulin in Adipocytes. Endocrinology 158(4):791-803 [PubMed]
  2. Herbst EAF, George MAJ, Brebner K, Holloway GP, Kane DA, (2017) Lactate is oxidized outside of the mitochondrial matrix in rodent brain. Applied Physiology, Nutrition, and Metabolism : [PubMed]
  3. Newell C, Kane CL, Kane DA, (2016) Mitochondrial substrate specificity in beetle flight muscle: assessing respiratory oxygen flux in small samples from Dermestes maculatus and Tenebrio molitor. Physiological Entomology 41(2):96-102
  4. Hughes MC, Ramos SV, Turnbull PC, Nejatbakhsh A, Baechler BL, Tahmasebi H, Laham R, Gurd BJ, Quadrilatero J, Kane DA, Perry CGR, (2015) Mitochondrial bioenergetics and fibre type assessments in microbiopsy vs Bergstrom percutaneous sampling of human skeletal muscle. Frontiers in Physiology : [PubMed]
  5. Elustondo PA, Negoda A, Kane CL, Kane DA, Pavlov EV, (2015) Spermine selectively inhibits high-conductance, but not low-conductance calcium-induced permeability transition pore. Biochimica et Biophysica Acta (BBA)-Bioenergetics 1847(2):231-240 [PubMed]
  6. Kane DA, (2014) Lactate oxidation at the mitochondria: a lactate-malate-aspartate shuttle at work. Frontiers in Neuroscience 8(366):1-6 [PubMed]
  7. Smith ME, Tippetts TS, Brassfield ES, Tucker BJ, Ockey A, Swensen AC, Anthonymuthu TS, Washburn TD, Kane DA, Prince JT, Bikman BT, (2013) Mitochondrial fission mediates ceramide-induced metabolic disruption in skeletal muscle. Biochemical Journal 456(3):427-39 [PubMed]
  8. Kane DA, Pavlov E, (2013) Calculation of ion currents across the inner membrane of functionally intact mitochondria. Channels 7(6):1-6 [PubMed]
  9. Elustondo PA, White AE, Hughes MC, Brebner K, Pavlov E, Kane DA, (2013) Physical and functional association of lactate dehydrogenase (LDH) with skeletal muscle mitochondria. The Journal of Biological Chemistry 288(35):25309-17 [PubMed]
  10. Perry CGR, Kane DA, Lanza IR, Neufer PD, (2013) Methods for assessing mitochondrial function in diabetes. Diabetes 62(4):1041-53 [PubMed]