Dal Alert!

Receive alerts from Dalhousie by text message.

X

Petra C. Kienesberger

PhD (University of Graz, Austria)


Assistant Professor

Department member since 2013

DMNB 138, Saint John
506-636-6971
pkienesb@dal.ca
Lab Homepage

Research:

My research focuses on understanding molecular mechanisms of metabolic disorders. Specifically, I am investigating the role of lipid metabolism and signalling in the development of obesity and diabetes-related comorbidities.


Research Areas

Keywords:
Energy metabolism, adipocytes, isolated cardiomyocytes, histology, live cell imaging, molecular imaging, molecular cloning, enzyme overexpression and knockdown, lipid analysis

Graduate Students

Andrew Cowie PhD
Kenneth D'Souza PhD
Carine Nzirorera MSc

Lab Personnel

Leticia Lima Summer student-alumni
Chih-Wei Lin Summer student-alumni
Lester Perez Research Associate

Publications

  1. Kienesberger, P., (2015) Myocardial metabolic abnormalities and cardiac dysfunction. Pathophysiology and Pharmacotherapy of Cardiovascular Disease. Springer:in press
  2. Rachakonda, V.P., Reeves, V.L., Aljammal J., Wills, R.C., Trybula, J.S., DeLany, J.P., Kienesberger, P.C., Kershaw, E.E., (2015) Serum autotaxin is independently associated with hepatic steatosis in women with severe obesity. Obesity (Silver Spring) in press: [PubMed]
  3. Zordoky, B.N., Nagendran, J., Pulinilkunnil, T., Kienesberger, P.C., Masson, G., Waller, T.J., Kemp, B.E., Steinberg, G., Dyck, J.R., (2014) AMPK-Dependent Inhibitory Phosphorylation of ACC Is Not Essential for Maintaining Myocardial Fatty Acid Oxidation. Circ Res. 115(5):518-524 [PubMed]
  4. Pulinilkunnil T, Kienesberger PC, Nagendran J, Waller TJ, Young ME, Kershaw EE, Korbutt G, Haemmerle G, Zechner R, Dyck JR., (2013) Myocardial Adipose Triglyceride Lipase Overexpression Protects Diabetic Mice From the Development of Lipotoxic Cardiomyopathy. Diabetes. 62(5):1464-77 [PubMed]
  5. McLean BA, Kienesberger PC, Wang W, Masson G, Zhabyeyev P, Dyck JR, Oudit GY., (2013) Enhanced recovery from ischemia-reperfusion injury in PI3Kα dominant negative hearts: investigating the role of alternate PI3K isoforms, increased glucose oxidation and MAPK signaling. J Mol Cell Cardiol. 54:9-18 [PubMed]
  6. Lou PH, Zhang L, Lucchinetti E, Heck M, Affolter A, Gandhi M, Kienesberger PC, Hersberger M, Clanachan AS, Zaugg M., (2013) Infarct-remodelled hearts with limited oxidative capacity boost fatty acid oxidation after conditioning against ischaemia/reperfusion injury. Cardiovasc Res. 97(2):251-61. [PubMed]
  7. Kienesberger PC, Pulinilkunnil T, Nagendran J, Dyck JR., (2013) Myocardial triacylglycerol metabolism. J Mol Cell Cardiol. 55:101-10. [PubMed]
  8. Nagendran J, Kienesberger PC, Pulinilkunnil T, Zordoky BN, Sung MM, Kim T, Young ME, Dyck JR., (2013) Cardiomyocyte specific adipose triglyceride lipase overexpression prevents doxorubicin induced cardiac dysfunction in female mice Heart 99:1041-47 [PubMed]
  9. Kienesberger PC, Pulinilkunnil T, Nagendran J, Young ME, Bogner-Strauss JG, Hackl H, Khadour R, Heydari E, Haemmerle G, Zechner R, Kershaw EE, Dyck JR, (2013) Early structural and metabolic cardiac remodelling in response to inducible adipose triglyceride lipase ablation Cardiovasc Res. 99:442-51 [PubMed]
  10. Pulinilkunnil T, Kienesberger PC, Nagendran J, Sharma N, Young ME, Dyck JR., (2013) Cardiac-specific adipose triglyceride lipase overexpression protects from cardiac steatosis and dilated cardiomyopathy following diet-induced obesity. Int J Obes (Lond). in press.: [PubMed]
  11. Sitnick MT, Basantani MK, Cai L, Schoiswohl G, Yazbeck CF, Distefano G, Ritov V, Delany JP, Schreiber R, Stolz DB, Gardner NP, Kienesberger PC, Pulinilkunnil T, Zechner R, Goodpaster BH, Coen P, Kershaw EE., (2013) Skeletal muscle triacylglycerol hydrolysis does not influence metabolic complications of obesity. Diabetes in press.: [PubMed]
  12. Nagendran J, Pulinilkunnil T, Kienesberger PC, Sung MM, Fung D, Febbraio M, Dyck JR., (2013) Cardiomyocyte-specific ablation of CD36 improves post-ischemic functional recovery. J Mol Cell Cardiol Cardiomyocyte-specific ablation of CD36 improves post-ischemic functional recovery.:180-8 [PubMed] [Article]
  13. Breckenridge RA, Piotrowska I, Ng KE, Ragan TJ, West JA, Kotecha S, Towers N, Bennett M, Kienesberger PC, Smolenski RT, Siddall HK, Offer JL, Mocanu MM, Yelon DM, Dyck JR, Griffin JL, Abramov AY, Gould AP, Mohun TJ., (2013) Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolism. PLoS Biol 11(9):e1001666 [PubMed] [Article]
  14. Willis MS, Bevilacqua A, Pulinilkunnil T, Kienesberger P, Tannu M, Patterson C., (2013) The role of ubiquitin ligases in cardiac disease. J Mol Cell Cardiol. in press: [PubMed] [Article]
  15. Kienesberger PC, Pulinilkunnil T, Sung MM, Nagendran J, Haemmerle G, Kershaw EE, Young ME, Light PE, Oudit GY, Zechner R, Dyck JR., (2012) Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction. Mol Cell Biol. 32(4):740-50. [PubMed]
  16. Kok BP, Kienesberger PC, Dyck JR, Brindley DN., (2012) Relationship of glucose and oleate metabolism to cardiac function in lipin-1 deficient (fld) mice. J Lipid Res. 53(1):105-18. [PubMed]
  17. Haemmerle G, Moustafa T, Woelkart G, BŁttner S, Schmidt A, van de Weijer T, Hesselink M, Jaeger D, Kienesberger PC, Zierler K, Schreiber R, Eichmann T, Kolb D, Kotzbeck P, Schweiger M, Kumari M, Eder S, Schoiswohl G, Wongsiriroj N, Pollak NM, Radner FP, P, (2011) ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1. Nat Med. 17(9):1076-85. [PubMed]
  18. Brindley DN, Kok BP, Kienesberger PC, Lehner R, Dyck JR., (2010) Shedding light on the enigma of myocardial lipotoxicity: the involvement of known and putative regulators of fatty acid storage and mobilization. Am J Physiol Endocrinol Metab. 298(5):E897-908. [PubMed]
  19. Schoiswohl G, Schweiger M, Schreiber R, Gorkiewicz G, Preiss-Landl K, Taschler U, Zierler KA, Radner FP, Eichmann TO, Kienesberger PC, Eder S, Lass A, Haemmerle G, Alsted TJ, Kiens B, Hoefler G, Zechner R, Zimmermann R., (2010) Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids. J Lipid Res. 51(3):490-9. [PubMed]
  20. Tsai JY, Kienesberger PC, Pulinilkunnil T, Sailors MH, Durgan DJ, Villegas-Montoya C, Jahoor A, Gonzalez R, Garvey ME, Boland B, Blasier Z, McElfresh TA, Nannegari V, Chow CW, Heird WC, Chandler MP, Dyck JR, Bray MS, Young ME., (2010) Direct regulation of myocardial triglyceride metabolism by the cardiomyocyte circadian clock. J Biol Chem. 29;285(5):2918-29. [PubMed]
  21. Kienesberger PC, Lee D, Pulinilkunnil T, Brenner DS, Cai L, Magnes C, Koefeler HC, Streith IE, Rechberger GN, Haemmerle G, Flier JS, Zechner R, Kim YB, Kershaw EE., (2009) Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling. J Biol Chem. 284(44):30218-29. [PubMed]
  22. Kienesberger PC, Oberer M, Lass A, Zechner R., (2009) Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions. J Lipid Res. 50 Suppl:S63-8. [PubMed]
  23. Zechner R, Kienesberger PC, Haemmerle G, Zimmermann R, Lass A., (2009) Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores. J Lipid Res. 50(1):3-21. [PubMed]
  24. Kienesberger PC, Lass A, Preiss-Landl K, Wolinski H, Kohlwein SD, Zimmermann R, Zechner R., (2008) Identification of an insulin-regulated lysophospholipase with homology to neuropathy target esterase. J Biol Chem. 283(9):5908-17. [PubMed]
  25. Lass A, Zimmermann R, Haemmerle G, Riederer M, Schoiswohl G, Schweiger M, Kienesberger P, Strauss JG, Gorkiewicz G, Zechner R., (2006) Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome. Cell Metab. 3(5):309-19. [PubMed]