enzymology, enzyme kinetics and inhibition, site-directed mutagenesis, protein & modification, UV-vis, AFM
My goal is to develop methods of treating illness using novel particles and delivery mechanisms. During my masters program I have designed a morpholino that represses the translation of AEBP1, a protein involved in many inflammatory diseases as well as breast cancer, significantly. The next goal is to deliver the morpholino to our model organism specifically to macrophages with a high delivery efficiency.
My current research interests involve the development of therapeutic drugs that can be administered efficiently. Many developments have been made in treating cancer, diabetes, and inflammatory diseases but most treatments are invasive and expensive. My main interest is in research of novel therapeutics and novel mechanisms for applying them. During my honours and post-graduate work I have learned many molecular and biochemical techniques such as primer and probe design, quantitative PCR, western blotting, embryonic morpholino microinjection, in vitro morpholino transfection, and am most recently becoming familiar with fluorescent microscopy.
Bachelor of Science (2005-2009)
University of New Brunswick, Dept. of Biology
Ontogeny of matrix metalloproteinases and analysis of their role in extracellular matrix remodelling.
Master of Science (2009-2012)
Dalhousie University, Dept. of Biochemsitry and Molecular Biology
AEBP1 alters matrix signalling and is responsive to inflammation in the mammary gland
Dalhousie University, Dept. of Biochemistry and Molecular Biology
Awards & Professional Activities
Scholarships & Awards
Best poster: New Directions in Enzymology (2015) ASBMB 2015 Annual Meeting
Poster presentation award: first place (2014) IHRTP Graduate Student Research Day
Gemcitabine Is a Competitive Inhibitor of Cytidine-5’-Triphosphate Synthase that Induces Enzyme Filament Polymerization (2015), ASBMB 2015 Annual Meeting
Mechanism of ammonia trafficking in the therapeutic target CTP synthase (2014) IHRTP Graduate Stduent Research Day
McCluskey G, Fitzpatrick C.M.M, and Crawford B.D. MMP11 is necessary for somite boundary remodeling and notochord elongation in the zebrafish (2009) AZUG's First Atlantic Zebrafish Research Symposium